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Pletal (Cilostazol)

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Pletal (Cilostazol) is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease. Although drugs similar to cilostazol have increased the risk of death in patients with congestive heart failure studies of significant size have not addressed people without the disease.

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About Pletal (Cilostazol):

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Brand name: Pletal Generic name: Cilostazol What is Pletal (Cilostazol)? Pletal widens arteries that supply blood to the legs. Pletal also improves circulation by keeping platelets in the blood from sticking together and clotting. Pletal is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs leading to pain while walking. Pletal improves your ability to walk longer distances without pain. Pletal may also be used for other purposes not listed in this medication guide. What is the most important information I should know about Pletal (cilostazol)? Do not take cilostazol if you have congestive heart failure. Pletal can make this condition worse. It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment. Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Take cilostazol on an empty stomach at least 30 minutes before or 2 hours after food. What should I discuss with my healthcare provider before taking Pletal (cilostazol)? Do not take cilostazol if you have congestive heart failure. Pletal can make this condition worse. Before using cilostazol tell your doctor if you have: • heart disease; or • liver disease. If you have any of these conditions you may need a dose adjustment or special tests to safely take this medication. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Pletal can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Pletal (cilostazol)? Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts or take it for longer than recommended by your doctor. Take each dose with a full glass of water. Pletal is usually taken twice a day at least 30 minutes before or 2 hours after breakfast or dinner. Take cilostazol at the same times each day. Follow your doctor's instructions. It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment. Store cilostazol at room temperature away from moisture heat and light. What happens if I miss a dose? Take the missed dose as soon as you remember. If it is almost time for your next dose skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include a severe headache diarrhea feeling light-headed fainting and fast or uneven heartbeats. What should I avoid while taking Pletal (cilostazol)? Grapefruit and grapefruit juice may interact with cilostazol. The interaction could lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Pletal (cilostazol) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face lips tongue or throat. Call your doctor at once if you have any of these serious side effects: • severe headache; • bloody urine painful urination; • fever chills body aches flu symptoms; • chest pain; • feeling short of breath even with mild exertion; or • swelling of your ankles or feet. Less serious side effects may include: • fast or pounding heartbeats; • diarrhea vomiting; • weakness dizziness; • leg cramps; • numbness or tingling; • joint pain; or • cough runny or stuffy nose. This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect that seems unusual or that is especially bothersome. What other drugs will affect Pletal (cilostazol)? Before taking cilostazol tell your doctor if you are using any of the following drugs: • clopidogrel (Plavix); • omeprazole (Prilosec Zegerid) or esomeprazole (Nexium); • erythromycin (E.E.S. Ery-Tab E-Mycin Erythrocin) or clarithromycin (Biaxin); • ketoconazole (Nizoral) fluconazole (Diflucan) or itraconazole (Sporanox); • diltiazem (Cardizem Tiazac); or • fluvoxamine (Luvox) fluoxetine (Prozac) sertraline (Zoloft) or nefazodone (Serzone). This list is not complete and there may be other drugs that can interact with cilostazol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins minerals herbal products and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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